Group Leader, Regenerative Medicine Program of IDIBELL
Group Leader of P-CMRC
Dr Jordi Guiu studied BS in Biology (2006), Biochemistry (2007) and a Master of Science in Molecular Biotechnology (2008). Then he did a PhD in Biomedicine (2012) from Pompeu Fabra University to study the genetic circuitry that controls the establishment of hematopoietic stem cells. Subsequently he joined Dr. Kim B. Jensen lab (Copenhagen University) as a postdoc, were he obtained a Marie Curie fellowship (2014-2019). His postdoctoral work focused on the specification of intestinal stem cells during development using fate mapping technologies, state of the art imaging, biophysical modeling and a plethora of sequencing techniques. In 2019 Dr. Guiu was appointed Assistant Professor in Copenhagen University. In September 2019, he joined the P-CMRC/IDIBELL as independent group leader.
Dr Guiu pursue a research program aimed at improving quality of life for cancer survivors, which suffer side effects of radiotherapy including acute and chronic inflammation of the intestine known as radiation-induced enteritis.
Mònica Díaz Ferrer
Mònica Díaz holds a bachelor degree in Biochemistry and a PhD in Physiology from the University of Barcelona. During the PhD she studied the role of insulin regulating the glucose transport in skeletal muscle under the supervision of Dr Josep Planas. After finishing her PhD she stayed at the same laboratory as a postdoctoral researcher and assistant professor for one year.
In 2008, she did a short stay as postdoctoral researcher in CIBBIM-Nanomedicine at the Vall d’Hebron Research Institute, in the laboratory of Dr Julián Cerón that was focused on the modeling of human diseases in C. elegans.
Then she moved to Omnia Molecular, a biotech company devoted to the design and development of new anti-infectives targeted at difficult-to-treat infections, as a project manager. She was involved in the setup and development of a proprietary technology platform. Among her tasks, she was in charge of the cell-based assays, in particular their design and miniaturization to be incorporated into a high-throughput screening campaign.
In 2013, she joined the CMR[B] as a research assistant. Here, she has been involved in several projects aimed to model in vitro different diseases through the generation of patient-derived pluripotent stem cells.
Since September 2020, she works as a research assistant in the Cell plasticity and Regeneration group at P-CMR[C].
Lab Member, Guiu Group
Ilias obtained his Integrated Master’s degree (2019) in Biological Applications & Technology from the University of Ioannina, Greece. His master thesis was focused on the investigation of the influence of ETS2 repressor factor (ERF) on maturation and differentiation of thymocytes using mice as an animal model under the direction of Dr. George Thyphronitis.
After finishing his master’s degree, he spent six months as an ERASMUS internship fellow working in the Department of Experimental and Health Sciences at the laboratory of Human Natural Killer Cell Biology of University Pompeu Fabra Barcelona under the supervision of Dr. Miguel López-Botet and Dr. Elisenda Alari. His research was focused on the Characterization of a novel facet of the antibody-dependent NK cell response to Epstein-Barr virus.
Currently, Ilias is working on his Ph.D. project focused on understanding the process of intestinal regeneration in order to develop treatments for cancer survivors using mice as an animal model, under the direction of Dr. Jordi Guiu at the Regenerative Medicine Program of IDIBELL.
I obtained my Master’s in Biochemistry at Ghent University, Belgium, where I completed my master thesis on Epithelial-to-mesenchymal transition during the development of melanoma skin cancer. This experience developed my interest in stem cell maintenance and differentiation. I started my PhD on the transcriptomic analysis of human embryonic stem cell derivation, pluripotency maintenance and differentiation, with a focus on Wnt signaling at the University Hospital in Ghent. Stem cell research introduced me to germ cell precursor stem cells and I continued my research as a postdoctoral researcher at the Leiden University Medical Center, in the department of Anatomy and Embryology in Leiden, the Netherlands. There I worked on in vitro differentiation of stem cells towards germ cells and in vitro maturation of human gonad tissues. Throughout my PhD and postdoc I applied single cell RNA sequencing techniques, using both SMART-Seq and 10X Genomics approaches, to analyze gene expression differences between different cell populations, in the coding environment R. Currently, I am interested in applying single cell transcriptomic analysis on intestinal organoids in different treatment conditions, in the context of enteritis after irradiation treatment for cancer. For this I will work with Dr. Guiu in the Cell Plasticity and Regeneration group at Idibell, where we aim to elucidate dedifferentiation mechanisms and signaling pathways of adult human intestinal cell types transitioning towards a stem cell state, in order to better regulate regeneration of intestinal tissues.
Borja Arozamena Villarrubia
Borja Arozamena obtained his BSc in Biotechnology at the University of Oviedo (2020). His Bachelor thesis was focused on the investigation of photodynamic therapy as a different approach against breast cancer, under the supervision of Dr. María Luisa Fernández. After, he enrolled in a MSc in Biomedical Research at Pompeu Fabra University (2021). During his master thesis, he had the opportunity to be part of the Cell Plasticity and Regeneration group led by Dr. Jordi Guiu. For his research, he worked with intestinal organoids and co-cultures with macrophages to study their role in intestinal regeneration in order to develop therapies for cancer survivors.
Throughout his master thesis, his interest in medicine regenerative and his concerns about understanding the process of intestinal regeneration have only gone to more. Therefore, he joined the Cell Plasticity and Regeneration group as a PhD student.
Olga Wienskowska obtained her BSc and Master in Biotechnology at Adam Mickiewicz University in Poland. Her Master thesis consisted of discovering the role of mismatch repair proteins in meiotic recombination while working on Arabidopsis thaliana plants.
In order to expand her knowledge, she started a Master in Nanotechnology at Autonomous University in Barcelona. The Master thesis she completed, was conducted in Catalan Institute of Nanoscience and Nanotechnology synthetizing fluorescent polymer nanoparticles, which were studied for biocompatibility in HeLa cells later on.
Currently, Olga joined the Cell plasticity and Regeneration group led by Dr. Jordi Guiu at IDIBELL in the position of research technician.
I obtained my bachelor degree in biotechnology in 2021 at the University of Milano-Bicocca, Italy. My thesis work had a pharmacology topic, talking about a new formulation of somatostatin for overcoming the BBB with a therapeutic potential for Alzheimer disease. I was supervised by Dr. Barbara Costa.
During my Bachelor I did an internship at Papa Giovanni XXIII Hospital in Bergamo, where I worked for Immunohematology and Transfusion Medicine Service, dealing with HLA typing and cytofluorimetry.
I’m now attending the Master of Science Course in Industrial Biotechnology with a particular interest in pharma companies and the development of new biological drugs.
For this reason I joined Dr. Guiu’s team: looking for new therapies with a strong emphasis on biological research and biotechnology, which give us many tools for innovation in health and medicine.
I will write my master thesis following the project of using human organoids to decipher the molecular mechanisms driving intestinal regeneration.